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Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.
Gene Name: | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 |
Synonyms: | NDST3, HNDST-3, NDST-3, N-HSST 3, HSST3 |
Target Sequences: | NM_004784 NP_004775.1 O95803 |
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