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Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
Gene Name: | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 |
Synonyms: | NDST2, NDST-2, HSST2, N-HSST 2, NST2 |
Target Sequences: | NM_003635 NP_003626.1 P52849 |
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