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Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
Gene Name: | Nedd4 family interacting protein 2 |
Synonyms: | NDFIP2, KIAA1165, N4WBP5A |
Target Sequences: | AB032991 BAA86479.1 Q9NV92 |
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