NCSTN / Nicastrin

nicastrin

NCSTN / Nicastrin is a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

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Antibodies (40)

Proteins (11)

ELISA Kits (1)

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Custom (1)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (2)

Primary (40)

Recombinant (8)

Target

NCSTN / Nicastrin (52)

Reactivity

Human (31)

Mouse (10)

Rat (17)

Bat (1)

Bovine (1)

Horse (1)

Pig (1)

Application

IHC (8)

IHC-P (3)

WB (31)

Flo (3)

ELISA (11)

ICC (1)

IF (5)

IP (3)

Peptide-ELISA (2)

Host

rabbit (40)

Product Group

IHCPlus (2)

Isotype

IgG (12)

Clonality

polyclonal pc (40)

Format

96-Well Microplate (1)

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (3)

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PE Conjugated (3)

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Epitope

aa35-534 (8)

aa420-655 (8)

C-Terminus (1)

aa659-709 (1)

aa72-88 (1)

aa99-133 (1)

Publications

No (52)

Tag

Fc (1)

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GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His,C-terminus (1)

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Mouse (2)

Rat (1)

Source

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E. coli (2)

HEK 293 Cells (4)

Human Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (3)

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IHC-plus™ NCSTN / Nicastrin Antibody LS-B1380

(4.0) Rating

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ NCSTN / Nicastrin Antibody LS-B530

(4.0) Rating

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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NCSTN / Nicastrin Antibody (PE) LS-C488465

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$293; 100 Tests/$376

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NCSTN / Nicastrin Antibody LS-C806059

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NCSTN / Nicastrin Antibody LS-C401888

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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NCSTN / Nicastrin Antibody LS-C488469

Antibody:

NCSTN / Nicastrin Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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NCSTN / Nicastrin Antibody LS-C660342

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$331

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NCSTN / Nicastrin Antibody LS-C488463

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

Select

NCSTN / Nicastrin Antibody (Preservative Free) LS-C818590

Antibody:

NCSTN / Nicastrin Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody

Reactivity:

Mouse

Applications:

ELISA, IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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NCSTN / Nicastrin Antibody LS-C405202

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

NCSTN / Nicastrin Antibody LS-C192373

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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NCSTN / Nicastrin Antibody (C-Terminus) LS-C25766

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$688

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NCSTN / Nicastrin Antibody LS-C488472

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

NCSTN / Nicastrin Antibody LS-C833948

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

NCSTN / Nicastrin Antibody LS-C488466

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

NCSTN / Nicastrin Antibody (aa659-709) LS-C761984

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (aa659-709) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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NCSTN / Nicastrin Antibody (aa99-133) LS-C392706

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (aa99-133) Antibody

Reactivity:

Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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NCSTN / Nicastrin Antibody LS-C488468

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo

Format:

Unconjugated

Price:

100 µl/$412

Select

NCSTN / Nicastrin Antibody LS-C488470

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$375; 200 µl/$473; 400 µl/$648

Select

NCSTN / Nicastrin Antibody LS-C488471

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

NCSTN / Nicastrin Antibody (aa420-655) LS-C295627

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (aa420-655) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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NCSTN / Nicastrin Antibody (aa72-88) LS-C313344

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (aa72-88) Antibody

Reactivity:

Rat, Pig, Horse, Bat, Bovine, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

NCSTN / Nicastrin Antibody LS-C749506

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

NCSTN / Nicastrin Antibody LS-C335080

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

NCSTN / Nicastrin Antibody (FITC) LS-C488464

Antibody:

NCSTN / Nicastrin Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

FITC Conjugated

Price:

25 Tests/$278; 100 Tests/$346

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