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NKp46/CD335 is expressed on activated and resting NK cells but not on T or B cells and belongs to a family of receptors termed natural cytotoxicity receptors (NCR). Their engagement induces a strong activation of NK-mediated cytolysis and direct correlation exists between the surface density of NCR and the ability of NK cells to kill various target cells.
Gene Name: | natural cytotoxicity triggering receptor 1 |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | NCR1, CD335, HNKp46, NK-p46, Lymphocyte antigen 94 homolog, NK cell-activating receptor, CD335 antigen, LY94, NKP46 |
Target Sequences: | NM_004829 NP_004820.2 O76036 |
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