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NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.
Gene Name: | neighbor of BRCA1 gene 1 |
Synonyms: | NBR1, 1A1-3B, 1A13B, CA125, M17S2, MIG19, Migration-inducing protein 19, Neighbor of BRCA1 gene 1, KIAA0049, Next to BRCA1 gene 1 protein, Protein 1A1-3B |
Target Sequences: | NM_005899 NP_005890.2 Q14596 |
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