NARF

nuclear prelamin A recognition factor

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

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Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

NARF (7)

Publications

No (7)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

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Human NARF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68554

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

20 µg/$1,107

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Human NARF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68555

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

20 µg/$1,107

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Human NARF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82459

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

20 µg/$150

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Human NARF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82461

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

20 µg/$215

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NARF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114495

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

100 µg/$710

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NARF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120556

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

100 µg/$494

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Human NARF Protein (Recombinant His, N-Terminal) (His41-Gln168) - LS-G133146

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

18.0kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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