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NAP1L4 encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
Gene Name: | Nucleosome Assembly Protein 1-like 4 |
Synonyms: | NAP1L4, NAP2L, NAP-2, NAP1L4b, NAP2, Nucleosome assembly protein 2, HNAP2 |
Target Sequences: | NM_005969 NP_005960.1 Q99733 |
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