NAP1 / TAB3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

NAP1 / TAB3 functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

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Proteins (2)

Type

Recombinant (2)

Target

NAP1 / TAB3 (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NAP1 / TAB3 Protein (Recombinant GST) (Full Length) - LS-G37152

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

105.1 kDa

Price:

2 µg/$439

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Human NAP1 / TAB3 Protein (Recombinant GST, N-terminus) (aa58-149) - LS-G64615

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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