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NAP1 / TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NAP1 / TAB3 functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
| Gene Name: | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
| Synonyms: | TAB3, MAP3K7IP3, NAP1, NFkB activating protein 1, TAK1-binding protein 3, TAB-3 |
| Target Sequences: | AAQ88279.1 Q8N5C8 |
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