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Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Gene Name: | nanos homolog 3 (Drosophila) |
Synonyms: | NANOS3, NANOS1L, Nanos homolog 3, Nanos homolog 3 (Drosophila), NOS-3 |
Target Sequences: | NM_001098622 NP_001092092.1 P60323 |
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