NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

☰ Filters

Products

Proteins (11)

Type

Over-Expression Lysate (6)

Recombinant (5)

Target

NALP3 / NLRP3 (11)

Product Group

Coronavirus Antibodies Proteins cDNAs (11)

Cytokine Release Syndrome (11)

Cytokine Release Syndrome Proteins (11)

Publications

No (10)

Yes (1)

Tag

6His, N-terminus + 6His, C-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Mouse (2)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

Human NALP3 / NLRP3 Protein (Recombinant GST) (Full Length) - LS-G36168

(4.0) Rating

(1) Publication(s)

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

144.6 kDa

Price:

2 µg/$439

Select

Human NALP3 / NLRP3 Protein (Recombinant 6His, N-terminus + 6His, C-terminus) (aa220-536) - LS-G140977

Source:

E. coli

Sequence Length:

316 AA

Tag:

6His, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

34.87 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

Select

Mouse NALP3 / NLRP3 Protein (Recombinant His, N-Terminal) (aa671-1033) - LS-G26053

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

43.9 kDa

Price:

10 µg/$281; 50 µg/$442; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176

Select

Human NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85552

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118 kDa

Price:

20 µg/$215

Select

Human NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85553

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.1 kDa

Price:

20 µg/$215

Select

Human NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85554

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118 kDa

Price:

20 µg/$215

Select

Human NALP3 / NLRP3 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G63534

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124644

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.1 kDa

Price:

100 µg/$710

Select

NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100410

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118 kDa

Price:

100 µg/$710

Select

NALP3 / NLRP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120121

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118 kDa

Price:

100 µg/$710

Select

Mouse NALP3 / NLRP3 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-153) - LS-G56834

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

Viewing 1-11 of 11 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.