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Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Gene Name: | CDGSH iron sulfur domain 2 |
Synonyms: | CISD2, CDGSH2, ERIS, Miner1, MitoNEET related 1, MitoNEET-related 1 protein, WFS2, NAF-1, Wolfram syndrome 2, CDGSH iron sulfur domain 2, ZCD2 |
Target Sequences: | Q8N5K1 Q8N5K1 |
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