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N-CoR / NCOR1

nuclear receptor corepressor 1

N-CoR / NCOR1 is a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

Gene Name: nuclear receptor corepressor 1
Synonyms: NCOR1, HCIT529I10, KIAA1047, N-CoR1, TRAC1, HN-CoR, N-CoR, Nuclear co-repressor n-cor, Nuclear receptor corepressor 1
Target Sequences: NM_006311 NP_006302.2 O75376

Publications (1)

1
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells. Beatrice Pflüger-Müller, James A Oo, Jan Heering, Timothy Warwick, Ewgenij Proschak, Stefan Günther, Mario Looso, Flávia Rezende, Christian Fork, Gerd Geisslinger, Dominique Thomas, Robert Gurke, Dieter Steinhilber, Marcel Schulz, Matthias S Leisegang, Ralf P Brandes. Basic research in cardiology. 2020 April;115:34. [PubMed:32323032] [PMC:PMC7176595] Related Antibodies: LS-C108878.

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Proteins (3)
Recombinant (3)
N-CoR / NCOR1 (3)
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GST, N-terminus (1)
His, N-Terminal (2)
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Mouse (1)
E. coli (2)
Wheat Germ Extract (1)
N-CoR / NCOR1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
N-CoR / NCOR1 Protein - Recombinant Nuclear Receptor Corepressor 1 (NCOR1) by SDS-PAGE
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E. coli
His, N-Terminal
35.8kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
N-CoR / NCOR1 Protein - Recombinant Nuclear Receptor Corepressor 1 (NCOR1) by SDS-PAGE
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E. coli
His, N-Terminal
35.9kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).