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Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
Gene Name: | Myosin VI |
Synonyms: | MYO6, DFNB37, DFNA22, Myosin VI, Myosin-VI, Unconventional myosin-VI, Unconventional myosin-6, KIAA0389 |
Target Sequences: | AL136093 CAI42823.1 Q9UM54 |
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