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The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.
Gene Name: | myomesin 2 |
Synonyms: | MYOM2, M-protein, M-band protein, Myomesin (M-protein) 2 (165kD), Myomesin 2, Myomesin family member 2, TTNAP, Myomesin (M-protein) 2, 165kDa, Myomesin-2 |
Target Sequences: | NM_003970 NP_003961.3 P54296 |
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