MYOC / Myocilin

myocilin, trabecular meshwork inducible glucocorticoid response

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

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Products

Antibodies (24)

Proteins (7)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (24)

Recombinant (5)

Sandwich (1)

Target

MYOC / Myocilin (32)

Reactivity

Human (25)

Mouse (5)

Rat (5)

Chimpanzee (3)

Gibbon (3)

Guinea pig (3)

Application

IHC (5)

IHC-P (2)

WB (21)

ELISA (4)

Peptide-ELISA (1)

RNAi (1)

Host

rabbit (23)

mouse (1)

Product Group

IHCPlus (1)

Isotype

IgG (8)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (23)

Clone

4F8 (1)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (11)

Epitope

aa224-471 (8)

aa101-150 (4)

Publications

No (32)

Sample Type

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ MYOC / Myocilin Antibody (clone 4F8) LS-B4382

(4.0) Rating

Antibody:

MYOC / Myocilin Mouse anti-Human Monoclonal (4F8) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, RNAi, WB

Format:

Unconjugated

Price:

50 µg/$485

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Human MYOC / Myocilin (Sandwich ELISA) ELISA Kit - LS-F6499

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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MYOC / Myocilin Antibody LS-C331563

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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MYOC / Myocilin Antibody LS-C809527

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MYOC / Myocilin Antibody LS-C778496

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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MYOC / Myocilin Antibody (aa224-471) LS-C295476

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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MYOC / Myocilin Antibody (aa224-471, HRP) LS-C713956

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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MYOC / Myocilin Antibody (aa224-471, Biotin) LS-C689003

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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MYOC / Myocilin Antibody (aa224-471, FITC) LS-C696054

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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MYOC / Myocilin Antibody (aa224-471, APC) LS-C719133

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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MYOC / Myocilin Antibody (aa224-471, PE) LS-C728028

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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MYOC / Myocilin Antibody (aa224-471, APC, Cy7) LS-C736938

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

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MYOC / Myocilin Antibody (aa224-471, Cy3) LS-C704945

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa224-471) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE
• APC, Cy7
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE
  • APC, Cy7
  • Cy3

Select

MYOC / Myocilin Antibody LS-C670727

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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MYOC / Myocilin Antibody (HRP) LS-C670728

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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MYOC / Myocilin Antibody (FITC) LS-C670729

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• FITC

• Unconjugated
• HRP
• FITC

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Human MYOC / Myocilin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66343

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.8 kDa

Price:

20 µg/$1,107

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MYOC / Myocilin Antibody LS-C192844

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

MYOC / Myocilin Antibody LS-C660332

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

MYOC / Myocilin Antibody LS-C768373

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

MYOC / Myocilin Antibody (aa101-150) LS-C187234

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa101-150) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

MYOC / Myocilin Antibody (aa101-150, HRP) LS-C466716

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa101-150) (HRP) Antibody

Reactivity:

Guinea pig, Human, Chimpanzee, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

MYOC / Myocilin Antibody (aa101-150, Biotin) LS-C466714

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa101-150) (Biotin) Antibody

Reactivity:

Guinea pig, Human, Chimpanzee, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

MYOC / Myocilin Antibody (aa101-150, FITC) LS-C466715

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal (aa101-150) (FITC) Antibody

Reactivity:

Guinea pig, Human, Chimpanzee, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MYOC / Myocilin Antibody LS-C667917

Antibody:

MYOC / Myocilin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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