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Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene Name: | myosin, heavy chain 2, skeletal muscle, adult |
Synonyms: | MYH2, Fast 2a myosin heavy chain, MyHC-IIa, Myosin heavy chain 2a, MyHC-2A, Myosin-2, MYHSA2, Myosin heavy chain 2, MYH2A, MYHas8, Myosin heavy chain IIa, Type IIA myosin heavy chain |
Target Sequences: | NM_017534 NP_060004.3 Q9UKX2 |
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