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E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.
Gene Name: | MYC binding protein 2, E3 ubiquitin protein ligase |
Synonyms: | MYCBP2, KIAA0916, Protein associated with Myc, MYC binding protein 2, Pam/highwire/rpm-1 protein, Myc-binding protein 2 |
Target Sequences: | NM_015057 |
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