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MVP / VAULT1 is the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Gene Name: | major vault protein |
Synonyms: | MVP, Major vault protein, VAULT1, LRP |
Target Sequences: | NM_017458 NP_059447.2 Q14764 |
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