Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
MVK is the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants.
Gene Name: | mevalonate kinase |
Synonyms: | MVK, Mevalonate kinase, Mevalonate kinase 1, MK, LRBP, MVLK, POROK3 |
Target Sequences: | NM_000431 NP_000422.1 Q03426 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.