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Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Gene Name: | MUS81 structure-specific endonuclease subunit |
Synonyms: | MUS81, SLX3 |
Target Sequences: | NM_025128 NP_079404.3 Q96NY9 |
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