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Vector Laboratories, Inc.
6737 Mowry Ave
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MURF1 / IRF
tripartite motif containing 63, E3 ubiquitin protein ligase
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
| Gene Name: | tripartite motif containing 63, E3 ubiquitin protein ligase |
| Family/Subfamily: | Tripartite Motif |
| Synonyms: | TRIM63, Iris RING finger protein, MURF-1, MURF1, MuRF2, IRF, RING finger protein 28, RNF28, Tripartite motif-containing 63, Tripartite motif containing 63, SMRZ |
| Target Sequences: | NM_032588 NP_115977.2 Q969Q1 |
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(21)
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(6)
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MURF1 / IRF
(31)
Reactivity
Human
(23)
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(14)
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(3)
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rabbit
(17)
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(6)
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(2)
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monoclonal mc
(2)
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(19)
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(1)
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(1)
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(5)
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(2)
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(2)
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(2)
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(15)
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aa186-235
(4)
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(4)
aa1-44
(1)
aa2-14
(1)
aa247-261
(1)
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No
(31)
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Cell Lysates
(2)
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(3)
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(3)
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(2)
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GST
(1)
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(1)
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(2)
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(3)
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(1)
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(1)
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(2)
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Purified
(1)
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$587
MURF1 / IRF Goat anti-Human Polyclonal (aa247-261) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MURF1 / IRF Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$424
MURF1 / IRF Rabbit anti-Human Polyclonal (aa251-300) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
MURF1 / IRF Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
MURF1 / IRF Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
MURF1 / IRF Goat anti-Human Polyclonal (aa2-14) Antibody
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
MURF1 / IRF Mouse anti-Human Monoclonal (7B8E1) Antibody
Human
ELISA, Flo, IF, IHC
Unconjugated
100 µl/$459
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
MURF1 / IRF Rabbit anti-Human Polyclonal (aa1-44) Antibody
Bovine, Pig, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$402
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Sandwich
96-Well Microplate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$412
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MURF1 / IRF Mouse anti-Human Monoclonal (6H6D4) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$459
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MURF1 / IRF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
MURF1 / IRF Rabbit anti-Human Polyclonal (aa186-235) Antibody
Human
WB
Unconjugated
100 µl/$424
MURF1 / IRF Rabbit anti-Human Polyclonal (aa186-235) (HRP) Antibody
Mouse, Guinea pig, Bovine, Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
MURF1 / IRF Rabbit anti-Human Polyclonal (aa186-235) (Biotin) Antibody
Mouse, Guinea pig, Bovine, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
MURF1 / IRF Rabbit anti-Human Polyclonal (aa186-235) (FITC) Antibody
Mouse, Guinea pig, Bovine, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
Custom
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
1 Plate/$669
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