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MTUS1 is a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
Gene Name: | microtubule associated tumor suppressor 1 |
Synonyms: | MTUS1, ATBP, ATIP, ATIP1, AT2 receptor-binding protein, AT2R binding protein, GK1, MTSG1, Transcription factor MTSG1, KIAA1288, MP44 |
Target Sequences: | AB033114 BAA86602.1 Q9ULD2 |
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