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MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.

Gene Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Synonyms: MTHFD2, NMDMC
Target Sequences: NM_006636 NP_006627.2 P13995

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Products
Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
MTHFD2 (8)
No (8)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
Myc-DDK (Flag) (5)
Cow (1)
Human (5)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (2)
MTHFD2 Protein - Purified recombinant protein MTHFD2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$1,107
MTHFD2 Protein - 12.5% SDS-PAGE of human MTHFD2 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.93 kDa
10 µg/$479; 25 µg/$670
MTHFD2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
MTHFD2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.7 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
37.9 kDa
20 µg/$150
MTHFD2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.9 kDa
100 µg/$494
MTHFD2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.7 kDa
100 µg/$494
MTHFD2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Viewing 1-8 of 8 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).