MTA2

metastasis associated 1 family, member 2

MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

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Proteins (3)

Type

Recombinant (3)

Target

MTA2 (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MTA2 Protein (Recombinant GST) (Full Length) - LS-G31537

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

101.4 kDa

Price:

2 µg/$439

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Human MTA2 Protein (Recombinant GST, N-terminus) (aa521-620) - LS-G61035

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MTA2 Protein (Recombinant His) (aa1-394) - LS-G25625

Source:

E. coli

Tag:

His

Molecular Weight:

48.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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