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MSL2

male-specific lethal 2 homolog (Drosophila)

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Gene Name: male-specific lethal 2 homolog (Drosophila)
Synonyms: MSL2, KIAA1585, Male-specific lethal 2-like 1, MSL2-like 1, MSL2L1, RNF184, MSL-2, RING finger protein 184, Male-specific lethal 2 homolog
Target Sequences: NM_018133 NP_060603.2 Q9HCI7

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
MSL2 (7)
No (7)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
MSL2 Protein - 12.5% SDS-PAGE of human MSL2L1 stained with Coomassie Blue
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Wheat Germ Extract
GST
88.9 kDa
10 µg/$479; 25 µg/$670
MSL2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
54.2 kDa
20 µg/$150
MSL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.4 kDa
20 µg/$150
MSL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.4 kDa
100 µg/$494
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HEK 293 Cells
Myc-DDK (Flag)
54.2 kDa
100 µg/$494
MSL2 Protein
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E. coli
His, N-Terminal
62.4 kDa
50 µg/$419
Viewing 1-7 of 7 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).