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Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
Gene Name: | male-specific lethal 1 homolog (Drosophila) |
Synonyms: | MSL1, HMSL1, Male-specific lethal 1 homolog, MSL-1, MSL1L1, Male-specific lethal 1-like 1, MSL1-like 1 |
Target Sequences: | NP_001012241.1 Q68DK7 |
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