MRPS12 / RPSM12

mitochondrial ribosomal protein S12

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

MRPS12 / RPSM12 (5)

Publications

No (5)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MRPS12 / RPSM12 Protein (Recombinant GST) (Full Length) - LS-G30245

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

40.92 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MRPS12 / RPSM12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77377

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

20 µg/$150

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Human MRPS12 / RPSM12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77378

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

20 µg/$150

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MRPS12 / RPSM12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108278

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

100 µg/$494

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MRPS12 / RPSM12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110767

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.1 kDa

Price:

100 µg/$494

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