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MRPL39
mitochondrial ribosomal protein L39
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.
| Gene Name: | mitochondrial ribosomal protein L39 |
| Synonyms: | MRPL39, C21orf92, L39mt, PRED66, RPML5, L5mt, MRP-L39, MRP-L5, MRPL5, MSTP003, PRED22 |
| Target Sequences: | NM_017446 NP_059142.2 Q9NYK5 |
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