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MRGPRX2 / MRGX2
MAS-related GPR, member X2
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
| Gene Name: | MAS-related GPR, member X2 |
| Family/Subfamily: | GPCR , Proadrenomedullin N-terminal peptide |
| Synonyms: | MRGPRX2, MRGX2, MAS-related GPR, member X2 |
| Target Sequences: | NM_054030 NP_473371.1 Q96LB1 |
Publications (1)
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