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Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP By similarity. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Gene Name: | melanocortin 2 receptor accessory protein 2 |
Synonyms: | MRAP2, BA51G5.2, C6orf117, RP11-51G5.2 |
Target Sequences: | NM_138409 NP_612418.2 Q96G30 |
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