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Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
Gene Name: | major histocompatibility complex, class I-related |
Synonyms: | MR1, HLALS, MHC class I-like antigen MR-1 |
Target Sequences: | NM_001531 NP_001522.1 Q95460 |
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