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MPO / Myeloperoxidase

myeloperoxidase

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. The gene for MPO is translocated in patients with acute promyelocytic leukemia and is mutated in hereditary MPO deficiency.

Gene Name: myeloperoxidase
Synonyms: MPO, Myeloperoxidase precursor, Myeloperoxidase
Target Sequences: NM_000250 NP_000241.1 P05164

Publications (7)

1
The glycosylation of myeloperoxidase. Ravnsborg T, Houen G, Hjrup P. Biochimica et biophysica acta. 2010 1804:2046-53. (ELISA; Human) [PubMed:20621206]
2
Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Sun Q, Zhong W, Zhang W, Zhou Z. American journal of physiology. Gastrointestinal and liver physiology. 2016 310:G205-14. (IHC; Human) [Full Text Article] [PubMed:26585415] [PMC:PMC4971814]
3
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Liver international : official journal of the International Association for the Study of the Liver. 2017 July;37:968-973. [Full Text Article] [PubMed:28345165] [PMC:PMC5479767]
4
Adenovirus 14p1 Immunopathogenesis during Lung Infection in the Syrian Hamster. Jay R Radke, Hunter J Covert, Fredrick Bauer, Vijayalakshmi Ananthanarayanan, James L Cook. Viruses. 2020 May;12: [Full Text Article] [PubMed:32486177] [PMC:PMC7354616] Related Antibodies: LS-C388920.
5
Decreased neutrophil levels in mice with traumatic brain injury after cape administration. Rizha Anshori Nasution, Andi Asadul Islam, Mochammad Hatta, Prihantono. Annals of medicine and surgery (2012). 2020 May;54:89-92. [Full Text Article] [PubMed:32419943] [PMC:PMC7217774]
6
Essential Role of IFN-? in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice. Ruichao Yue, Xiaoyuan Wei, Jiangchao Zhao, Zhanxiang Zhou , Wei Zhong. Frontiers in physiology. 2021 Jan;11:629141. [Full Text Article] [PubMed:33536944] [PMC:PMC7848155]
7
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
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MPO / Myeloperoxidase (27)
Human (9)
Mouse (8)
Rat (5)
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MPO / Myeloperoxidase ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Horse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$795
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$600
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
250 - 16000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$590
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Microplate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Saliva, Serum, Urine
1 Plate/$559
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$699
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$1,002
MPO / Myeloperoxidase ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
MPO / Myeloperoxidase ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
68.6 - 50000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$911
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.614 - 60 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$1,002
MPO / Myeloperoxidase ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
13.7 - 10000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$871
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$697
MPO / Myeloperoxidase ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$995; 1000 Wells/$1,434
MPO / Myeloperoxidase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
MPO / Myeloperoxidase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$582
MPO / Myeloperoxidase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).