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Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.
Gene Name: | M-phase phosphoprotein 8 |
Synonyms: | MPHOSPH8, M-phase phosphoprotein 8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, HSMPP8, RP11-523H24.1, Mpp8, TWA3 |
Target Sequences: | NM_017520 NP_059990.2 Q99549 |
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