MOB1A

MOB kinase activator 1A

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

MOB1A (8)

Publications

No (8)

Tag

6His, C-terminus (2)

GST (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human MOB1A Protein (Recombinant 6His, C-terminus) (Ser2-Arg216) - LS-G38829

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

26kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human MOB1A Protein (Recombinant GST) (Full Length) - LS-G34245

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.5 kDa

Price:

10 µg/$479; 25 µg/$670

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MOB1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111878

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

100 µg/$494

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Human MOB1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90874

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

20 µg/$150

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Human MOB1A Protein (Recombinant His-SUMO) (Full Length) - LS-G21949

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

40.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MOB1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71893

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

20 µg/$1,107

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Human MOB1A Protein (Recombinant His) - LS-G1089

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human MOB1A Protein (Recombinant 6His, C-terminus) (Ser2-Arg216) - LS-G140285

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

26.0 kDa

Price:

10 µg/$317; 50 µg/$524

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