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MNK / ATP7A

ATPase, Cu++ transporting, alpha polypeptide

MNK / ATP7A is a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed.

Gene Name: ATPase, Cu++ transporting, alpha polypeptide
Family/Subfamily: Transporter , ATPase - P type, type IB
Synonyms: ATP7A, Copper pump 1, Menkes disease ATPase, MNK, MK, SMAX3, Menkes syndrome, OHS, Copper-transporting ATPase 1, DSMAX, MC1
Target Sequences: NM_000052 NP_000043.4 Q04656

Publications (2)

1
Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. Alexandria Brumfield, Natasha Chaudhary, Dorothee Molle, Jennifer Wen, Johannes Graumann, Timothy E McGraw. Molecular biology of the cell. 2020 November;mbcE20060356. [Full Text Article] [PubMed:33175605] [PMC:PMC8098823] Related Antibodies: LS-C209614.
2
Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells. Anuttoma Ray, Jennifer Wen, Lucie Yammine, Jeff Culver, Isabella Supardi Parida, Jeonifer Garren, Liang Xue, Katherine Hales, Qing Xiang, Morris J Birnbaum, Bei B Zhang, Mara Monetti, Timothy E McGraw. Journal of cell science. 2023 December;136: [Full Text Article] [PubMed:38126809] [PMC:PMC10753500] Related Antibodies: LS-C209614.

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Products
Antibodies (39)
Primary (39)
MNK / ATP7A (39)
Human (37)
Mouse (26)
Rat (27)
Bat (3)
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IHC (23)
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WB (29)
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Peptide-ELISA (3)
rabbit (27)
mouse (11)
goat (1)
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IgG (17)
IgG2b (11)
monoclonal mc (11)
polyclonal pc (28)
S60-4 (11)
APC Conjugated (1)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Biotin Conjugated (5)
FITC Conjugated (5)
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PerCP Conjugated (1)
RPE Conjugated (1)
Unconjugated (19)
aa42-61 (9)
C-Terminus (6)
aa1403-1452 (4)
aa391-440 (3)
Internal (2)
His640 (1)
aa1-201 (1)
aa1212-1225 (1)
aa591-640 (1)
No (38)
Yes (1)
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (Biotin) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Biotin Conjugated
100 µg/$475
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (FITC) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
FITC Conjugated
100 µg/$472
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (PerCP) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
PerCP Conjugated
100 µg/$478
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (Atto 594) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 594 Conjugated
100 µg/$479
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (Atto 390) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 390 Conjugated
100 µg/$479
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (Atto 488) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 488 Conjugated
100 µg/$479
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (RPE) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
RPE Conjugated
100 µg/$477
MNK / ATP7A Antibody - Anti-MNK / ATP7A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (APC) (S60-4) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
APC Conjugated
100 µg/$478
MNK / ATP7A Antibody - Immunohistochemical analysis of ATP7A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MNK / ATP7A Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
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MNK / ATP7A Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$652
MNK / ATP7A Antibody - A: Marker, B: HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MNK / ATP7A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
MNK / ATP7A Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MNK / ATP7A Rabbit anti-Human Polyclonal (aa591-640) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
MNK / ATP7A Antibody - Immunohistochemistry image at a dilution of 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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MNK / ATP7A Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat
ICC, IHC, WB
Unconjugated
100 µg/$919
MNK / ATP7A Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using ATP7A Polyclonal Antibody at dilution of 1:50.
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MNK / ATP7A Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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MNK / ATP7A Mouse anti-Human Monoclonal (aa42-61) (S60-4) Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
100 µg/$665
MNK / ATP7A Antibody - Immunoblot on rat brain membranes.
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MNK / ATP7A Mouse anti-Human Monoclonal (S60-4) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$537
MNK / ATP7A Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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MNK / ATP7A Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MNK / ATP7A Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using ATP7A Polyclonal Antibody at dilution of 1:50.
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MNK / ATP7A Antibody - Immunohistochemistry of paraffin-embedded Rat kidney using ATP7A Polyclonal Antibody at dilution of 1:100 (40x lens).
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MNK / ATP7A Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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MNK / ATP7A Rabbit anti-Human Polyclonal (His640) Antibody
Mouse, Rat, Human
IHC
Unconjugated
50 µl/$321; 100 µl/$403
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MNK / ATP7A Rabbit anti-Human Polyclonal (aa1-201) Antibody
Human
WB
Unconjugated
100 µl/$414
Viewing 1-25 of 39 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).