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Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.
Gene Name: | multimerin 1 |
Synonyms: | MMRN1, Endothelial cell multimerin, EMILIN4, ECM, EMILIN-4, GPIa*, Multimerin, Prepromultimerin, Glycoprotein Ia*, MMRN, Multimerin 1, Multimerin-1 |
Target Sequences: | NM_007351 NP_031377.2 Q13201 |
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