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MMP9 / Gelatinase B

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Gene Name: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP9, 92kd gelatinase, 92 kDa gelatinase, Matrix metalloproteinase-9, MMP-9, CLG4B, Gelatinase B, GELB, Macrophage gelatinase, MANDP2
Target Sequences: NM_004994 NP_004985.2 P14780

Publications (8)

1
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:10649-54. (IHC) [PubMed:20498063] [PMC:PMC2890809]
2
Is it really necessary to delay intranasal steroid treatment after FESS? An animal study. Bayraktar C, Atmaca S, Guvenc D, Karayigit MO, Atmaca E, Yarim M, Aksoy A. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2013 148:314-23. (IHC-P; Rabbit) [PubMed:23232827]
3
Tumor necrosis factor-like weak inducer of apoptosis or fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice. Tarín C, Fernández-Laso V, Sastre C, Madrigal-Matute J, Gómez M, Zaragoza C, Egido J, Burkly LC, Martín-Ventura JL, Blanco-Colio LM. Journal of the American Heart Association. 2014 3: (IHC; Mouse) [Full Text Article] [PubMed:25092786] [PMC:PMC4310358] Related Antibodies: LS-B2486.
4
Aging alters the immunological response to ischemic stroke. Ritzel RM, Lai YJ, Crapser JD, Patel AR, Schrecengost A, Grenier JM, Mancini NS, Patrizz A, Jellison ER, Morales-Scheihing D, Venna VR, Kofler JK, Liu F, Verma R, McCullough LD. Acta neuropathologica. 2018 July;136:89-110. [Full Text Article] [PubMed:29752550] [PMC:PMC6015099]
5
Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model. Hyesook Lee, Whuisu Shim, Chae Eun Kim, So Yeon Choi, Haeshin Lee, Jaewook Yang. Investigative ophthalmology & visual science. 2017 March;58:1682-1691. [Full Text Article] [PubMed:28319642] Related Antibodies: LS-B2486.
6
Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus. Jung Hae Yoon, Kun Cho, Timothy J Garrett, Paul Finch, Malcolm Maden. Scientific reports. 2020 Jan;10:166. [Full Text Article] [PubMed:31932597] [PMC:PMC6957500] Related Antibodies: LS-B2486.
7
Telocytes are major constituents of the angiogenic apparatus. Soha A Soliman. Scientific reports. 2021 Mar;11:5775. [Full Text Article] [PubMed:33707590] [PMC:PMC7952407] Related Antibodies: LS-C31757.
8
Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL. Molecular therapy : the journal of the American Society of Gene Therapy. 2012 Jan;20:37-45. [Full Text Article] [PubMed:21915104] [PMC:PMC3255598] Related Antibodies: LS-B2486.
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MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Microplate
Human
10 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$573
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Microplate
Equine
49 - 12000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
4.69 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$731
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
MMP9 / Gelatinase B ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$562
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
24.69 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
MMP9 / Gelatinase B ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Horse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$795
MMP9 / Gelatinase B ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
MMP9 / Gelatinase B ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$744
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).