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MMP25 / Leukolysin
matrix metallopeptidase 25
MMP25 is a Metallopeptidase M10A type protease. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. Former prototype NM_022718.2 was permanently suppressed because currently there is insufficient support for the transcript. Caution: MMP25 has been referred to as MMP20; however, MMP20 is a distinct gene on human chromosome 11q22.
| Gene Name: | matrix metallopeptidase 25 |
| Family/Subfamily: | Protease , Metallopeptidase M10A |
| Synonyms: | MMP25, Matrix metalloproteinase 25, MMP20A, MMPL1, MT6MMP, Matrix metallopeptidase 25, Matrix metallopeptidase-like 1, MMP-25, MT6-MMP, MTMMP6, Leukolysin, Matrix metalloproteinase 20, Matrix metalloproteinase-25, MT-MMP 6, MT-MMP6 |
| Target Sequences: | NM_022468 NP_071913.1 Q9NPA2 |
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