MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

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Products

Proteins (22)

Type

Over-Expression Lysate (2)

Recombinant (20)

Target

MMP2 (22)

Publications

No (22)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (4)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (16)

Mouse (2)

Rat (3)

Source

293T Cells (1)

E. coli (10)

HEK 293 Cells (4)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (2)

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Human MMP2 Protein (Recombinant) - LS-G437

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

62.0 kDa

Price:

2 µg/$268; 10 µg/$349

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Human MMP2 Protein (Recombinant GST) (Full Length) - LS-G29349

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MMP2 Protein (Recombinant 6His, N-terminus) (Tyr110-Cys660) - LS-G26369

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

73.9 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human MMP2 Protein (Recombinant His, N-Terminal) (aa445-660) - LS-G11556

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25.9 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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Human MMP2 Protein (Recombinant His) - LS-G2853

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human MMP2 Protein (Recombinant 6His, C-terminus) (Ala30-Cys660) - LS-G38899

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.01kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human MMP2 Protein (Recombinant GST, N-terminus) (aa561-660) - LS-G59258

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MMP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64809

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.9 kDa

Price:

20 µg/$1,107

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Human MMP2 Protein (Recombinant) (Met1-Cys660) - LS-G97699

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72 kDa

Price:

20 µg/$451; 100 µg/$1,191

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Human MMP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74250

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.88 kDa

Price:

20 µg/$150

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Human MMP2 Protein (Recombinant) - LS-G37788

Tag:

None

Biological Activity:

Biologically active

Price:

10 µg/$492

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MMP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116582

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.88 kDa

Price:

100 µg/$494

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Human MMP2 Protein (Recombinant) - LS-G131381

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~62 kDa

Price:

10 µg/$291; 100 µg/$931; 1 mg/$3,781

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Human MMP2 Protein (Recombinant) - LS-G137852

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 1 EU/µg (determined by LAL method).

Molecular Weight:

This 652 amino acid recombinant protein has a predicted molecular mass of approximately 73.2 kD. The protein migrates at about 73 kD in DTT-reducing conditions and about 73 kD in non-reducing conditions by SDS-PAGE.The predicted N-terminal amino acid is A

Price:

10 µg/$355; 25 µg/$497; 100 µg/$1,186; 500 µg/$3,043

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Mouse MMP2 Protein (Recombinant) - LS-G137626

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

This 663 amino acid recombinant protein has a predicted molecular mass of approximately 74.5 kD. The protein migrates at about 72 kD in DTT-reducing conditions and about 71 kD in non-reducing conditions by SDS-PAGE.The predicted N-terminal amino acid is I

Price:

10 µg/$355; 25 µg/$497

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Human MMP2 Protein (Recombinant His, N-Terminal) - LS-G133754

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

64kDa

Price:

10 µg/$339; 50 µg/$805; 200 µg/$1,433; 100 µg/$1,217; 1 mg/$2,732; 500 µg/$2,227; 5 mg/$5,621; 2 mg/$2,999

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Rat MMP2 Protein (Recombinant His-SUMO) (aa110-662) - LS-G20971

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

78.1 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat MMP2 Protein (Recombinant His) (aa110-662) - LS-G23028

Source:

Yeast

Tag:

His

Molecular Weight:

64.1 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human MMP2 Protein (Recombinant 6His, C-terminus) (Ala30-Cys660) - LS-G140521

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.01 kDa

Price:

10 µg/$317; 50 µg/$524

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Rat MMP2 Protein (Recombinant His, N-Terminal) (Tyr445-Cys662) - LS-G133078

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.1kDa

Price:

10 µg/$286; 50 µg/$472; 200 µg/$942; 100 µg/$752; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human MMP2 Protein (Recombinant His) (aa110-660) - LS-G11553

Source:

E. coli

Tag:

His

Molecular Weight:

63.6 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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Mouse MMP2 Protein (Recombinant His, N-Terminal) (Tyr445-Cys662) - LS-G133049

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25.8kDa

Price:

10 µg/$297; 50 µg/$542; 200 µg/$1,065; 100 µg/$865; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430

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