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Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Gene Name: | matrix metallopeptidase 17 (membrane-inserted) |
Family/Subfamily: | Protease , Metallopeptidase M10A |
Synonyms: | MMP17, MMP-17, MT4-MMP, Matrix metalloproteinase-17, MTMMP4, MT-MMP 4, MT4MMP |
Target Sequences: | NM_016155 AAH45610.1 Q9ULZ9 |
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