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MMP13
matrix metallopeptidase 13 (collagenase 3)
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
| Gene Name: | matrix metallopeptidase 13 (collagenase 3) |
| Family/Subfamily: | Protease , Metallopeptidase M10A |
| Synonyms: | MMP13, Collagenase 3, Matrix metalloproteinase-13, Interstitial collagenase, MANDP1, MMP-13, CLG3 |
| Target Sequences: | NM_002427 NP_002418.1 P45452 |
Publications (6)
1
Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Cake MA, Read RA, Corfield G, Daniel A, Burkhardt D, Smith MM, Little CB. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2013 21:226-36. (IHC; Sheep)
[PubMed:23069853]
2
The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs. Sun Y, Kiraly AJ, Cox M, Mauerhan DR, Hanley EN Jr. Experimental and therapeutic medicine. 2018 April;15:3320-3328. (Rat)
[Full Text Article]
[PubMed:29545850]
[PMC:PMC5841021]
3
Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment. Brandt A, Jin CJ, Nolte K, Sellmann C, Engstler AJ, Bergheim I. Nutrients. 2017 September;9:pii: E1013. (Rat)
[Full Text Article]
[PubMed:28906444]
[PMC:PMC5622773]
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Products
Antibodies
(149)
Type
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(149)
Target
MMP13
(149)
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(96)
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(38)
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(36)
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(69)
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(8)
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(8)
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(8)
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Publications
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(149)
Fast Shipping
MMP13 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
MMP13 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
MMP13 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
MMP13 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
MMP13 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MMP13 Rabbit anti-Human Polyclonal (aa253-282) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
MMP13 Rabbit anti-Mouse Polyclonal (aa66-238) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
MMP13 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI2D11) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MMP13 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI3H3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Mouse anti-Human Monoclonal (aa104-471) (Carrier-free) (OTI3H3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI3A7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Mouse anti-Human Monoclonal (aa104-471) (Carrier-free) (OTI3A7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI2D8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Mouse anti-Human Monoclonal (aa104-471) (Carrier-free) (OTI2D8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI1G5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI3G1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI2A6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
MMP13 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MMP13 Mouse anti-Human Monoclonal (aa104-471) (OTI4B3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MMP13 Rabbit anti-Human Polyclonal (aa10-59) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MMP13 Rabbit anti-Human Polyclonal (aa253-282) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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product results
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