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MLKL
mixed lineage kinase domain-like
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
| Gene Name: | mixed lineage kinase domain-like |
| Family/Subfamily: | Protein Kinase , Provisional protein kinase |
| Synonyms: | MLKL |
| Target Sequences: | NM_152649 NP_689862.1 Q8NB16 |
Publications (4)
1
RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. Sureshbabu A, Patino E, Ma KC, Laursen K, Finkelsztein EJ, Akchurin O, Muthukumar T, Ryter SW, Gudas L, Choi AMK, Choi ME. JCI insight. 2018 June;3:pii: 98411. [Full Text Article]
[PubMed:29875323]
[PMC:PMC6124406]
2
Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells. Van Hoecke L, Raes L, Stremersch S, Brans T, Fraire JC, Roelandt R, Declercq W, Vandenabeele P, Raemdonck K, Braeckmans K, Saelens X. International journal of molecular sciences. 2019 August;20:E4254. [Full Text Article]
[PubMed:31480289]
[PMC:PMC6747363]
3
Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies. Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P Wicks, Hitoshi Kohsaka, Shinsuke Yasuda. Nature communications. 2022 January;13:166. [Full Text Article]
[PubMed:35013338]
[PMC:PMC8748624]
☰ Filters
Products
ELISA Kits
(4)
Type
Sandwich
(4)
Target
MLKL
(4)
Reactivity
Human
(2)
Mouse
(1)
Rat
(1)
Format
96-Well Strip Plate
(4)
Publications
No
(3)
Yes
(1)
Sample Type
Cell Lysates
(2)
Plasma
(2)
Serum
(2)
Tissue Homogenates
(2)
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$792
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$848
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