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MLKL

mixed lineage kinase domain-like

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Gene Name: mixed lineage kinase domain-like
Family/Subfamily: Protein Kinase , Provisional protein kinase
Synonyms: MLKL
Target Sequences: NM_152649 NP_689862.1 Q8NB16

Publications (4)

1
RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. Sureshbabu A, Patino E, Ma KC, Laursen K, Finkelsztein EJ, Akchurin O, Muthukumar T, Ryter SW, Gudas L, Choi AMK, Choi ME. JCI insight. 2018 June;3:pii: 98411. [Full Text Article] [PubMed:29875323] [PMC:PMC6124406]
2
Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells. Van Hoecke L, Raes L, Stremersch S, Brans T, Fraire JC, Roelandt R, Declercq W, Vandenabeele P, Raemdonck K, Braeckmans K, Saelens X. International journal of molecular sciences. 2019 August;20:E4254. [Full Text Article] [PubMed:31480289] [PMC:PMC6747363]
3
Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies. Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P Wicks, Hitoshi Kohsaka, Shinsuke Yasuda. Nature communications. 2022 January;13:166. [Full Text Article] [PubMed:35013338] [PMC:PMC8748624]
4
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy. Jia Guo, Zehui Guo, Yanju Huang, Suchen Ma, Bo Yan, Chenjie Pan, Zhaodi Jiang, Fengchao Wang, Zhiyuan Zhang, Yuwei Da, Xiaodong Wang, Zhengxin Ying. Proceedings of the National Academy of Sciences of the United States of America. 2022 April;119:e2121552119. [Full Text Article] [PubMed:35344427] [PMC:PMC9168919]
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Products
Antibodies (38)
Primary (38)
MLKL (38)
Human (31)
Mouse (16)
Rat (6)
Bovine (3)
Chimpanzee (3)
Gibbon (3)
Monkey (3)
Pig (3)
IHC (20)
IHC-P (7)
WB (22)
ELISA (15)
IF (2)
Peptide-ELISA (1)
rabbit (29)
mouse (9)
Product Group
IHCPlus (2)
IgG (24)
IgG1 (3)
IgG2a,k (1)
monoclonal mc (8)
polyclonal pc (30)
3B2 (1)
8H7 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (27)
aa443-472 (7)
aa1-471 (4)
aa107-156 (4)
40-120 aa, N-terminal (1)
aa110-135 (1)
pS358 (1)
No (38)
MLKL Antibody - Anti-MLKL antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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MLKL Mouse anti-Human Monoclonal (3B2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MLKL Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MLKL Rabbit anti-Human Polyclonal (aa107-156) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MLKL Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MLKL Rabbit anti-Human Polyclonal (aa107-156) (HRP) Antibody
Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
MLKL Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MLKL Rabbit anti-Human Polyclonal (aa107-156) (Biotin) Antibody
Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
MLKL Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MLKL Rabbit anti-Human Polyclonal (aa107-156) (FITC) Antibody
Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) Antibody
Mouse
WB
Unconjugated
200 µl/$393
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MLKL Rabbit anti-Human Polyclonal (aa1-471) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
MLKL Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MLKL Rabbit anti-Human Polyclonal (aa110-135) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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MLKL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
MLKL Antibody
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MLKL Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
MLKL Antibody - Western blot of MLKL antibody
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MLKL Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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MLKL Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
MLKL Antibody - Immunohistochemistry of paraffin-embedded Human colon carcinoma using MLKL Polyclonal Antibody at dilution of 1:200 (40x lens).
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MLKL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MLKL Antibody - Western blot analysis of extracts of various cell lines, using MLKL antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
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MLKL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
MLKL Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using MLKL antibody at dilution of 1:100 (40x lens).
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MLKL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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MLKL Rabbit anti-Mouse Polyclonal (aa443-472) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
MLKL Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using MLKL Polyclonal Antibody at dilution of 1:85(×200)
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MLKL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MLKL Antibody - Immunohistochemistry of paraffin-embedded Human tonsil using MLKL Polyclonal Antibody at dilution of 1:100 (40x lens).
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MLKL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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MLKL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
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MLKL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 38 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).