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Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Gene Name: | Meckel Syndrome, Type 1 |
Synonyms: | MKS1, BBS13, FABB proteome-like protein, MES, POC12, Meckel syndrome type 1 protein, MKS, Meckel syndrome, type 1 |
Target Sequences: | NM_017777 NP_060247.2 Q9NXB0 |
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