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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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MICU2 / EFHA1
mitochondrial calcium uptake 2
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca2+, avoiding energy dissipation and cell-death triggering.
| Gene Name: | mitochondrial calcium uptake 2 |
| Synonyms: | MICU2, EF hand domain family A1, EFHA1, Smhs2 homolog |
| Target Sequences: | Q8IYU8 Q8IYU8 |
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