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Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization Probable. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
Gene Name: | microtubule associated monooxygenase, calponin and LIM domain containing 1 |
Synonyms: | MICAL1, MICAL, NICAL, CasL interacting molecule, MICAL-1 |
Target Sequences: | NM_022765 NP_073602.3 Q8TDZ2 |
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