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E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Gene Name: | mindbomb E3 ubiquitin protein ligase 2 |
Synonyms: | MIB2, Mindbomb homolog 2, Novel zinc finger protein, Mind bomb homolog 2, ZZANK1, SKD, Skeletrophin, ZZZ5, Novelzin |
Target Sequences: | NP_001164157.1 Q96AX9 |
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