Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Gene Name: | mindbomb E3 ubiquitin protein ligase 1 |
Synonyms: | MIB1, DIP-1, DIP1, Mindbomb homolog 1, KIAA1323, Mind bomb homolog 1, Ubiquitin ligase protein MIB1, Ubiquitin ligase mind bomb, ZZZ6, DAPK-interacting protein 1, Mib, ZZANK2 |
Target Sequences: | AB037744 BAA92561.1 Q86YT6 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.